Projects
Our lab is interested in the way that single macromolecules, experiencing only the laws of physics in their local environment, are collectively orchestrated to give rise to living, self-maintaining systems. We primarily work on the dynamic, structurally complex membranes of subcellular organelles, which host crucial machinery for the regulation and coordination of nearly every major process of life in both health and disease.
Can local membrane shape affect ER protein behavior and function?
How are damaged proteins removed from the ER and degraded?
How does a cell know when a protein is safe to secrete?
How are lipids shuttled to a growing autophagic crescent?
How do cells coordinate reactions in physically separate compartments?
How do cells compute signals to make functional decisions?