Obara Lab @ UC San Diego Integrating technology and biology to link the scales of life.

Publications

Please browse through our publications and preprints for more details about our work!

Highlighted

Motion of VAPB molecules reveals ER mitochondria contact site subdomains
Motion of VAPB molecules reveals ER mitochondria contact site subdomains
Christopher J. Obara, Jonathon Nixon-Abell, Andrew S. Moore, Federica Riccio, David P. Hoffman, …, Jean-Baptiste Masson, Harald F. Hess, Christopher P. Calderon, Craig Blackstone, Jennifer Lippincott-Schwartz
Nature  ·  24 Jan 2024  ·  doi:10.1038/s41586-023-06956-y
Article

All

2024

Motion of VAPB molecules reveals ER mitochondria contact site subdomains
Motion of VAPB molecules reveals ER mitochondria contact site subdomains
Christopher J. Obara, Jonathon Nixon-Abell, Andrew S. Moore, Federica Riccio, David P. Hoffman, …, Jean-Baptiste Masson, Harald F. Hess, Christopher P. Calderon, Craig Blackstone, Jennifer Lippincott-Schwartz
Nature  ·  24 Jan 2024  ·  doi:10.1038/s41586-023-06956-y
Article

2023

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity
PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity
Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, …, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux, Yusuke Hirabayashi
Cold Spring Harbor Laboratory  ·  22 Aug 2023  ·  doi:10.1101/2023.08.22.554218
Preprint
Simultaneous photoactivation and high-speed structural tracking reveal diffusion-dominated motion in the endoplasmic reticulum
Simultaneous photoactivation and high-speed structural tracking reveal diffusion-dominated motion in the endoplasmic reticulum
Matteo Dora, Christopher J. Obara, Tim Abel, Jennifer Lippincott-Schwarz, David Holcman
Cold Spring Harbor Laboratory  ·  25 Apr 2023  ·  doi:10.1101/2023.04.23.537908
Preprint
Fast and sensitive GCaMP calcium indicators for imaging neural populations
Fast and sensitive GCaMP calcium indicators for imaging neural populations
Yan Zhang, Márton Rózsa, Yajie Liang, Daniel Bushey, Ziqiang Wei, …, Eric R. Schreiter, Karel Svoboda, Jeremy P. Hasseman, Ilya Kolb, Loren L. Looger
Nature  ·  15 Mar 2023  ·  doi:10.1038/s41586-023-05828-9
Article

2022

Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscale
Christopher J. Obara, Andrew S. Moore, Jennifer Lippincott-Schwartz
Cold Spring Harbor Perspectives in Biology  ·  19 Sep 2022  ·  doi:10.1101/cshperspect.a041259
Article
Unraveling trajectories of diffusive particles on networks
Unraveling trajectories of diffusive particles on networks
Yunhao Sun, Zexi Yu, Christopher J. Obara, Keshav Mittal, Jennifer Lippincott-Schwartz, Elena F. Koslover
Physical Review Research  ·  06 Jun 2022  ·  doi:10.1103/PhysRevResearch.4.023182
Article

2021

ER proteins decipher the tubulin code to regulate organelle distribution
ER proteins decipher the tubulin code to regulate organelle distribution
Pengli Zheng, Christopher J. Obara, Ewa Szczesna, Jonathon Nixon-Abell, Kishore K. Mahalingan, Antonina Roll-Mecak, Jennifer Lippincott-Schwartz, Craig Blackstone
Nature  ·  15 Dec 2021  ·  doi:10.1038/s41586-021-04204-9
Article
Deep learning enables fast and dense single-molecule localization with high accuracy
Deep learning enables fast and dense single-molecule localization with high accuracy
Artur Speiser, Lucas-Raphael Müller, Philipp Hoess, Ulf Matti, Christopher J. Obara, Wesley R. Legant, Anna Kreshuk, Jakob H. Macke, Jonas Ries, Srinivas C. Turaga
Nature Methods  ·  01 Sep 2021  ·  doi:10.1038/s41592-021-01236-x
Article
Actin cables and comet tails organize mitochondrial networks in mitosis
Actin cables and comet tails organize mitochondrial networks in mitosis
Andrew S. Moore, Stephen M. Coscia, Cory L. Simpson, Fabian E. Ortega, Eric C. Wait, …, C. Alexander Boecker, Teng-Leong Chew, Julie A. Theriot, Jennifer Lippincott-Schwartz, Erika L. F. Holzbaur
Nature  ·  03 Mar 2021  ·  doi:10.1038/s41586-021-03309-5
Article
Advances in Confocal Microscopy and Selected Applications
Advances in Confocal Microscopy and Selected Applications
W. Matt Reilly, Christopher J. Obara
Methods in Molecular Biology  ·  01 Jan 2021  ·  doi:10.1007/978-1-0716-1402-0_1
Article

2017

Rational Engineering of Photoconvertible Fluorescent Proteins for Dual Color Fluorescence Nanoscopy Enabled by a Triplet State Mechanism of Primed Conversion
Rational Engineering of Photoconvertible Fluorescent Proteins for Dual Color Fluorescence Nanoscopy Enabled by a Triplet State Mechanism of Primed Conversion
Manuel Alexander Mohr, Andrei Yu. Kobitski, Lluc Rullan Sabater, Karin Nienhaus, Christopher John Obara, Jennifer Lippincott‐Schwartz, Gerd Ulrich Nienhaus, Periklis Pantazis
Angewandte Chemie International Edition  ·  11 Jul 2017  ·  doi:10.1002/anie.201706121
Article

2016

Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
Jonathon Nixon-Abell, Christopher J. Obara, Aubrey V. Weigel, Dong Li, Wesley R. Legant, …, Kirsten Harvey, Harald F. Hess, Eric Betzig, Craig Blackstone, Jennifer Lippincott-Schwartz
Science  ·  28 Oct 2016  ·  doi:10.1126/science.aaf3928
Article

2015

Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection
Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection
Susana V. Bardina, Daniela Michlmayr, Kevin W. Hoffman, Christopher J. Obara, Janet Sum, Israel F. Charo, Wuyuan Lu, Alexander G. Pletnev, Jean K. Lim
The Journal of Immunology  ·  01 Nov 2015  ·  doi:10.4049/jimmunol.1500352
Article

2013

Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses
Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses
Christopher J. Obara, Kimberly A. Dowd, Julie E. Ledgerwood, Theodore C. Pierson
Virology  ·  01 Mar 2013  ·  doi:10.1016/j.virol.2012.11.016
Article

2011

Chemokine Receptor Ccr2 Is Critical for Monocyte Accumulation and Survival in West Nile Virus Encephalitis
Chemokine Receptor Ccr2 Is Critical for Monocyte Accumulation and Survival in West Nile Virus Encephalitis
Jean K. Lim, Christopher J. Obara, Aymeric Rivollier, Alexander G. Pletnev, Brian L. Kelsall, Philip M. Murphy
The Journal of Immunology  ·  01 Jan 2011  ·  doi:10.4049/jimmunol.1003003
Article